Smile House (Regional Center for CLP San Paolo Hospital, Milano) Azienda Ospedaliera San Paolo 20142 Milano

Principle contact details

Contact name:Roberto Brusati and Giovanna Garattini
Address:Via Antonio di Rudinì 8, 20142 Milano, Italy
Web address:Visit website

Map of location

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Other team members

Surgeon:Roberto Brusati, Luca Autelitano
Speech therapist:Angela Rezzonico
Orthodontist:Giovanna Garattini and Costanza Meazzini
Otolaryngologist:Giovanni Felisati
Specialist nurse:Ornella Squaratti
Psychologist:Egidio Moja
Patient follow up:All the team

Support group

Support group address:Gruppo Genitori San Paolo
Roberto Maspes

Annual case load

Cleft palate:27 cases of 2011
Cleft lip (CL) Unilateral (UCL):13 cases of 2011
Bilateral (BCL):9 cases of 2011
Number of syndromic cases:13 cases of 2011

Primary surgical protocol

Timing of first repair and type of operation.

Complete UCLP:4-6 months lip, nose, soft palate; 18-24 months hard palate and GAP; 4-6 months less than 10 cm all in one
Complete BCLP:4-6 months lip, nose, soft palate; 18-24 months hard palate and GA P
Isolated CP:10-12 months

Record collection protocol

Are records routinely collected at specific ages?Yes
Does this conform to WHO timing recommendations
(birth, 5, 10, 15 and 20 years)?

State coverage of costs

Are the costs of the following treatments covered by the state (free to the patient)?

Surgery costs:All
Orthodontic costs:Part
Speech and language therapy costs:All

Clinical research

Clinical team members who are or would like to be involved in clinical research:

Member details:BRUSATI - SURGERY - Clinical trials



Current research activity and data collection

Type(s) of software used:Word, Excel
Details of publications:1: Brusati R, Colletti G. The role of maxillary osteotomy in the treatment of
arhinia. J Oral Maxillofac Surg. 2012 May;70(5):e361-8. Epub 2012 Feb 23. PubMed
PMID: 22364860.

2: Meazzini MC, Allevia F, Mazzoleni F, Ferrari L, Pagnoni M, Iannetti G,
Bozzetti A, Brusati R. Long-term follow-up of syndromic craniosynostosis after Le
Fort III halo distraction: a cephalometric and CT evaluation. J Plast Reconstr
Aesthet Surg. 2012 Apr;65(4):464-72. Epub 2012 Jan 9. PubMed PMID: 22227504.

3: Meazzini MC, Tortora C, Morabito A, Garattini G, Brusati R. Factors that
affect variability in impairment of maxillary growth in patients with cleft lip
and palate treated using the same surgical protocol. J Plast Surg Hand Surg. 2011
Sep;45(4-5):188-93. PubMed PMID: 22150138.

4: Montirosso R, Fedeli C, Murray L, Morandi F, Brusati R, Perego GG, Borgatti R.
The role of negative maternal affective states and infant temperament in early
interactions between infants with cleft lip and their mothers. J Pediatr Psychol.
2012 Mar;37(2):241-50. Epub 2011 Oct 17. PubMed PMID: 22004886.

5: Cesaretti C, Gentilin B, Bianchi V, Melloni G, Bonaguro M, Rossi C, Meazzini
C, Brusati R, Lalatta F. Occurrence of complete arhinia in two siblings with a
clinical picture of Treacher Collins syndrome negative for TCOF1, POLR1D and
POLR1C mutations. Clin Dysmorphol. 2011 Oct;20(4):229-31. PubMed PMID: 21772136.

6: Meazzini MC, Brusati R, Caprioglio A, Diner P, Garattini G, Giannì E, Lalatta
F, Poggio C, Sesenna E, Silvestri A, Tomat C. True hemifacial microsomia and
hemimandibular hypoplasia with condylar-coronoid collapse: diagnostic and
prognostic differences. Am J Orthod Dentofacial Orthop. 2011 May;139(5):e435-47.
PubMed PMID: 21536185.

8: Meazzini MC, Mazzoleni F, Bozzetti A, Brusati R. Comparison of mandibular
vertical growth in hemifacial microsomia patients treated with early distraction
or not treated: follow up till the completion of growth. J Craniomaxillofac Surg.
2012 Feb;40(2):105-11. Epub 2011 Mar 31. PubMed PMID: 21454084.

11: Meazzini M, Lematti L, Mazzoleni F, Rabbiosi D, Bozzetti A, Brusati R.
Vertical excess of the premaxilla in bilateral cleft lip and palate patients: a
protocol for treatment. J Craniofac Surg. 2010 Mar;21(2):499-502. PubMed PMID:

12: Meazzini MC, Brusati R, Diner P, Giannì E, Lalatta F, Magri AS, Picard A,
Sesenna E. The importance of a differential diagnosis between true hemifacial
microsomia and pseudo-hemifacial microsomia in the post-surgical long-term
prognosis. J Craniomaxillofac Surg. 2011 Jan;39(1):10-6. Epub 2010 Apr 24. PubMed
PMID: 20456963.

13: Meazzini MC, Rossetti G, Morabito A, Garattini G, Brusati R. Photometric
evaluation of bilateral cleft lip and palate patients after primary columella
lengthening. Cleft Palate Craniofac J. 2010 Jan;47(1):58-65. PubMed PMID:

14: Meazzini MC, Rossetti G, Garattini G, Semb G, Brusati R. Early secondary
gingivo-alveolo-plasty in the treatment of unilateral cleft lip and palate
patients: 20 years experience. J Craniomaxillofac Surg. 2010 Apr;38(3):185-91.
Epub 2009 Jul 9. PubMed PMID: 19589688.

16: Brusati R, Pedrazzoli M, Colletti G. Functional results after condylectomy in
active laterognathia. J Craniomaxillofac Surg. 2010 Apr;38(3):179-84. Epub 2009
Jun 5. PubMed PMID: 19501516.

17: Brusati R, Donati V, Marelli S, Ferrari M. Management of a case of arhinia. J
Plast Reconstr Aesthet Surg. 2009 Jul;62(7):e206-10. Epub 2009 Apr 26. PubMed
PMID: 19401274.

19: Meazzini MC, Capasso E, Morabito A, Garattini G, Brusati R. Comparison of
growth results in patients with unilateral cleft lip and palate after early
secondary gingivoalveoloplasty and secondary bone grafting: 20 years follow up.
Scand J Plast Reconstr Surg Hand Surg. 2008;42(6):290-5. PubMed PMID: 18991170.

20: Meazzini MC, Giussani G, Morabito A, Semb G, Garattini G, Brusati R. A
cephalometric intercenter comparison of patients with unilateral cleft lip and
palate: analysis at 5 and 10 years of age and long term. Cleft Palate Craniofac
J. 2008 Nov;45(6):654-60. Epub 2008 Feb 20. PubMed PMID: 18956937.

22: Del Guercio F, Meazzini MC, Garattini G, Morabito A, Semb G, Brusati R. A
cephalometric intercentre comparison of patients with unilateral cleft lip and
palate at 5 and 10 years of age. Eur J Orthod. 2010 Feb;32(1):24-7. Epub 2008 Sep
27. PubMed PMID: 18820305.

23: Meazzini MC, Donati V, Garattini G, Brusati R. Maxillary growth impairment in
cleft lip and palate patients: a simplified approach in the search for a cause. J
Craniofac Surg. 2008 Sep;19(5):1302-7. PubMed PMID: 18812855.

25: Meazzini MC, Mazzoleni F, Bozzetti A, Brusati R. Does functional appliance
treatment truly improve stability of mandibular vertical distraction osteogenesis
in hemifacial microsomia? J Craniomaxillofac Surg. 2008 Oct;36(7):384-9. Epub
2008 Apr 28. PubMed PMID: 18442918.

26: Tortora C, Meazzini MC, Garattini G, Brusati R. Prevalence of abnormalities
in dental structure, position, and eruption pattern in a population of unilateral
and bilateral cleft lip and palate patients. Cleft Palate Craniofac J. 2008
Mar;45(2):154-62. PubMed PMID: 18333651.
Research grant funding received:Yes
Willing to share Powerpoint presentations:Yes

EU Biobank

Stored CLP DNA samples available for use in future studies:

Number for CP:*** please ask to professor Michele Rubini (

Potential clinical research activities

Clinical research activities interested in being involved in:

Randomised clinical trials:Yes
Inter-centre comparison of outcome:Yes

National cleft lip and palate / craniofacial scientific organisation

Organisation details:S.I.L.P.S,