Service de Chirurgie Maxillo-Faciale et Plastique pédiatriques Centre des Malformations de la Face et de la Cavité Buccale Paris

Principle contact details

Contact name:Professor Marie-Paule VAZQUEZ
Address:149 rue de Sèvres, 75015 PARIS
Telephone:00 33 1 44 49 43 21
Web address:Visit website

Map of location

View Larger Map

Other team members

Surgeon:Pr MP Vazquez, Pr A Picard, Dr V Soupre, Dr PA Diner, Dr G Franchi, Dr F Dr Dr E Galliani, Dr N. Kadlub, Dr M Mitrofanoff, Dr F Zazurca,
Speech therapist:C Trichet-Zbinden, V Charpillet, C Chapuis, S Dhab, MC Trummer
Orthodontist:Drs B Vi-Fane, C Tomat, A Majourau-Bouriez, B Houssamo
Clinical geneticist:Pr A Munnich, Pr S Lyonnet, Dr J Amiel, Dr S Marlin,
Otolaryngologist:Dr N Leboulanger, Dr N Loundon, Dr I Rouillon,
Specialist nurse:F Mongredien
Psychologist:P Gavelle
Other:Pedodontists - Dr I Pavlov, Dr M Molla, Pr A Berdal
Patient follow up:Every surgeon

Annual case load

Cleft palate:70
Pierre Robin:35
Cleft lip (CL) Unilateral (UCL):140 (unilateral + bilateral)
Number of syndromic cases:Goldenhar= 28, Treacher Collins=10, Van der Woude=8, Stickler=3, CHARGE=3, deletion 22q11=3

Primary surgical protocol

Timing of first repair and type of operation.

Complete UCLP:Cheiloplasty: 3 m, veloplasty: 3 or 6 m, hard palate: 12 m, GPP 5 y
Complete BCLP:Bilateral cheiloplasty in one stage 3 m
Isolated CP:Veloplasty: 3 or 6 months, hard palate: 12 months, GPP 5 y

Record collection protocol

Are records routinely collected at specific ages?Yes
Does this conform to WHO timing recommendations
(birth, 5, 10, 15 and 20 years)?

State coverage of costs

Are the costs of the following treatments covered by the state (free to the patient)?

Surgery costs:All
Orthodontic costs:All
Speech and language therapy costs:All

Clinical research

Clinical team members who are or would like to be involved in clinical research:

Member details:Vazquez MP - Surgery - Cohort studies, clinical trials

Picard A - Surgery - Cohort studies, clinical trials

Kadlub N - Surgery - Cohort studies, clinical trials

Vi-Fane B - Orthodontics - Cohort studies, clinical trials

Berdal A - Odontology - Molecular research

Non-clinical and laboratory research

Non-clinical and laboratory team members who are or would like to be involved in clinical research:

Member details:Soupre V - Surgery -

Galliani E - Surgery -

Diner PA - Surgery -

Mitrofanoff M - Surgery -

Majourau A - Orthodontics -

Trichet C - Speech pathologist -

Chapuis C - Speech pathologist -

Current research activity and data collection

Type(s) of software used:Software CEMARA
Participation in inter-centre studies:Yes
Details of studies:National PHRC (Hospital national program for clinical research). Title Participation in inter Relational development in children with cleft lip and palate: influence of the waiting period prior to the first surgical intervention and parental psychological perceptions of the abnormality »
Participation in other collaborations (projects):Yes
Details of projects:1) Research Unit Laboratoire Biologie orofaciale et Pathologies INSERM UMRS 873, (Professeur Ariane Berdal, odontologist). Centre des Cordeliers, 75006 Paris

2) multicentric study (PHRC)
phD in collaboration with molecular genetic unit (Pr M Vikkula, Brussels)
Published research papers:Yes
Details of publications:Published papers :

1: Guyot A, Soupre V, Vazquez MP, Picard A, Rosenblatt J, Garel C, Gonzales M,
Marlin S, Benifla JL, Jouannic JM. [Prenatal diagnosis of cleft lip with or
without cleft palate: Retrospective study and review.]. J Gynecol Obstet Biol
Reprod (Paris). 2012 Sep 24. pii: S0368-2315(12)00211-6. doi:
10.1016j.jgyn.2012.08.002. [Epub ahead of print] French. PubMed PMID: 23017738.

2: Grollemund B, Guedeney A, Vazquez MP, Picard A, Soupre V, Pellerin P, Simon E, Velten M, Dissaux C, Kauffmann I, Bruant-Rodier C, Danion-Grilliat A. Relational
Development in children with cleft lip and palate: influence of the waiting period prior to the first surgical intervention and parental psychological perceptions of the abnormality.
BMC Pediatr. 2012 Jun 8;12:65. PubMed PMID: 22682069; PubMed Central PMCID: PMC3436730.

3: Galliani E, Burglen L, Kadlub N, Just W, Sznajer Y, de Villemeur TB, Soupre V, Picard A, Vazquez MP.
Craniofacial phenotype in the branchio-oculo-facial syndrome: four case reports.
Cleft Palate Craniofac J. 2012 May;49(3):357-64. Epub 2011 May 3. PubMed PMID: 21539471.

4: Picard A, Diner PA, Galliani E, Tomat C, Vazquez MP, Carls FP. Five years
experience with a new intraoral maxillary distraction device (RID).
Br J Oral Maxillofac Surg. 2011 Oct;49(7):546-51. Epub 2010 Dec 9. PubMed PMID: 21145630.

5: Renault F, Baudon JJ, Galliani E, Flores-Guevara R, Marlin S, Garabedian EN,Vazquez MP.
Facial, lingual, and pharyngeal electromyography in infants with Pierre Robin sequence.
Muscle Nerve. 2011 Jun;43(6):866-71. doi:10.1002mus.21991. Epub 2011 Apr 7. PubMed PMID: 21480295.

6: Hyon C, Marlin S, Chantot-Bastaraud S, Mabboux P, Beaujard MP, Al Ageeli E, Vazquez MP, Picard A, Siffroi JP, Portnoï MF.
A new 17p13.3 microduplication including the PAFAH1B1 and YWHAE genes resulting from an unbalanced X;17 translocation.
Eur J Med Genet. 2011 May-Jun;54(3):287-91. Epub 2010 Dec 31.PubMed PMID: 21195811.

7: Grollemund B, Galliani E, Soupre V, Vazquez MP, Guedeney A, Danion A.
The impact of cleft lip and palate on the parent-child relationships
Arch Pediatr. 2010 Sep;17(9):1380-5. Epub 2010 Aug 3. Review. French. PubMed PMID: 20685092.

8: Trichet-Zbinden C, de Buys Roessingh A, Herzog G, Martinez H, Oger P, Delerive-Taieb MF, Soupre V, Picard A, Vazquez MP, Galliani E, Hohlfeld J.
Orthophonic guidance in a multidisciplinary cleft team
Arch Pediatr. 2010 Jun;17(6):790-1. French. PubMed PMID: 20654895.

9: Galliani E, Bach C, Vi-Fane B, Soupre S, Pavlov I, Trichet-Zbinden C, Delerive MF, Leca JB, Picard A, Vazquez MP.
Reference Centers, Cleft Centers. Network of care.
Arch Pediatr. 2010 Jun;17(6):785-6. French. PubMed PMID: 20654892.

10: Benko S, Fantes JA, Amiel J, Kleinjan DJ, Thomas S, Ramsay J, Jamshidi N, Essafi A, Heaney S, Gordon CT, McBride D, Golzio C, Fisher M, Perry P, Abadie V, Ayuso C, Holder-Espinasse M, Kilpatrick N, Lees MM, Picard A, Temple IK, Thomas P, Vazquez MP, Vekemans M, Roest Crollius H, Hastie ND, Munnich A, Etchevers HC, Pelet A, Farlie PG, Fitzpatrick DR, Lyonnet S.
Highly conserved non-coding elements on either side of SOX9 associated with Pierre Robin sequence.
Nat Genet. 2009 Mar;41(3):359-64. Epub 2009 Feb 22. PubMed PMID: 19234473.

11: Baudon JJ, Renault F, Goutet JM, Biran-Mucignat V, Morgant G, Garabedian EN, Vazquez MP.
Assessment of dysphagia in infants with facial malformations.
Eur J Pediatr. 2009 Feb;168(2):187-93. Epub 2008 May 22. PubMed PMID: 18496714.

12: Chevrier C, Bahuau M, Perret C, Iovannisci DM, Nelva A, Herman C, Vazquez MP, Francannet C, Robert-Gnansia E, Lammer EJ, Cordier S.
Genetic susceptibilities in the association between maternal exposure to tobacco smoke and the risk of nonsyndromic oral cleft.
Am J Med Genet A. 2008 Sep 15;146A(18):2396-406. PubMed PMID: 18698632.

13: Bénateau H, Diner PA, Soubeyrand E, Vazquez MP, Picard A.
Maxillary sequelae in cleft patients. Causes of maxillary hypoplasia and possible prevention.
Rev Stomatol Chir Maxillofac. 2007 Sep;108(4):297-300. Epub 2007 Aug 8. French. PubMed PMID: 17689577.

14: Bahuau M, Houdayer C, Tredano M, Soupre V, Couderc R, Vazquez MP.
FOXC2 truncating mutation in distichiasis, lymphedema, and cleft palate.
Clin Genet.2002 Dec;62(6):470-3. PubMed PMID: 12485195.

15: Baudon JJ, Renault F, Goutet JM, Flores-Guevara R, Soupre V, Gold F, Vazquez MP.
Motor dysfunction of the upper digestive tract in Pierre Robin sequence as assessed by sucking-swallowing electromyography and esophageal manometry. J
Pediatr. 2002 Jun;140(6):719-23. PubMed PMID: 12072876.

16: Houdayer C, Bonaïti-Pellié C, Erguy C, Soupre V, Dondon MG, Bürglen L, Cougoureux E, Couderc R, Vazquez MP, Bahuau M.
Possible relationship between the van der Woude syndrome (vWS) locus and nonsyndromic cleft lip with or without
cleft palate (NSCLP).
Am J Med Genet. 2001 Nov 15;104(1):86-92. PubMed PMID:11746036.

17: Houdayer C, Portnoï MF, Vialard F, Soupre V, Crumière C, Taillemite JL, Couderc R, Vazquez MP, Bahuau M.
Pierre Robin sequence and interstitial deletion 2q32.3-q33.2.
Am J Med Genet. 2001 Aug 15;102(3):219-26. PubMed PMID: 11484197.

18: Renault F, Flores-Guevara R, Soupre V, Vazquez MP, Baudon JJ.
Neurophysiological brainstem investigations in isolated Pierre Robin sequence.
Early Hum Dev. 2000 May;58(2):141-52. PubMed PMID: 10854801.

19: Houdayer C, Soupre V, Karcenty B, Vazquez MP, Odent S, Lacombe D, Le Bouc Y, Munnich A, Bahuau M.
1q32-q41 microdeletion with reference to Van der Woude syndrome and allied clefting entities.
Am J Med Genet. 2000 Mar 13;91(2):161-3.PubMed PMID: 10748420.

20: Lassale C, Vazquez MP, Delorme M, Lupold M.
Early treatment of labiopalatine clefts. Their management and anesthetic problems.
Rev Stomatol Chir Maxillofac. 1984;85(6):477-83. French. PubMed PMID: 6596692.
Research grant funding received:Yes
Willing to share Powerpoint presentations:Yes

Potential clinical research activities

Clinical research activities interested in being involved in:

Randomised clinical trials:Yes
Inter-centre comparison of outcome:Yes
Prospective study:Yes

Potential laboratory based research activities

Laboratory based research activities interested in being involved in:

Laboratory genetics/genomics research:Yes

National cleft lip and palate / craniofacial scientific organisation

Organisation details:Yes
AFFF: Association Francophone des Fentes faciales
General secretary : Pr. Philippe Pellerin ; Service de Chirurgie Plastique ; Hôpital Roger Salengro; CHU de Lille ; 5
9037 Lille Cedex ; France, Téléphone : (+33) 3 20 44 54 22