Estonian Cleft Team (University of Tartu + North Estonia Medical Center, Tallinn)

Principle contact details

Contact name:Triin Jagomägi
Address:University of Tartu,
Department of Stomatology
Raekojapl. 6,
Tartu 51003,
Web address:Visit website

Map of location

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Other team members

Surgeon:Marianne Soots (Tartu), Airi Sokk, Heleia Nestal-Zibo (Tallinn)
Speech therapist:Reet Veenpere (Tartu); Birgit Kaasik, Veronika Raudsalu (Tallinn)
Orthodontist:Triin Jagomägi (Tartu, Tallinn), Katri Herman (Tallinn)
Clinical geneticist:Katrin õunap, Riina Žordania, Kairit Joost
Otolaryngologist:Priit Kasenõmm (Tartu),Aet Saarts, Marika Tirmaste, K. Lüüs (Tallinn)
Specialist nurse:S. Müürsepp
Psychologist:T. Tänavsuu
Patient follow up:Triin Jagomägi, Airi Sokk

Support group

Support group

Annual case load

Cleft palate:6
Cleft lip (CL) Unilateral (UCL):4
Bilateral (BCL):1
Number of syndromic cases:3 CL, 5 CLP, 6CP

Primary surgical protocol

Timing of first repair and type of operation.

Complete UCLP:lip 4-6 months, palate 1-1,5years
Complete BCLP:lip 4-6 months, palate 1-1,5years
Isolated CP:1-1,5 years

Record collection protocol

Are records routinely collected at specific ages?Yes
Does this conform to WHO timing recommendations
(birth, 5, 10, 15 and 20 years)?

State coverage of costs

Are the costs of the following treatments covered by the state (free to the patient)?

Surgery costs:All
Orthodontic costs:All
Speech and language therapy costs:All
Comments on the service provision:orthodontics and speech and langue is covered by insurance up to 19 years

Clinical research

Clinical team members who are or would like to be involved in clinical research:

Member details:Triin Jagomägi orthodontist, team leader DDS, MSc, MOrth RCEd, PhD, University of Tartu
Heleia Nestal Zibo, oral surgeon, Ph.D student, North Estonia Medical center, Tallinn
Marianne Soots, oral surgeon, Tartu University

We have research activity in speech evaluation (Triin Jagomägi)

Non-clinical and laboratory research

Non-clinical and laboratory team members who are or would like to be involved in clinical research:

Member details:Estonian Genome Center, University of Tartu

Prof. Andres Metspalu-
Tiit Nikopensius MSc, Ph.D-

Current research activity and data collection

Type(s) of software used:all possible
Published research papers:Yes
Details of publications:Variation in FGF1, FOXE1, and TIMP2 genes is associated with nonsyndromic cleft lip with or without cleft palate.
Nikopensius T, Kempa I, Ambrozaitytė L, Jagomägi T, Saag M, Matulevičienė A, Utkus A, Krjutškov K, Tammekivi V, Piekuse L, Akota I, Barkane B, Krumina A, Klovins J, Lace B, Kučinskas V, Metspalu A.
Birth Defects Res A Clin Mol Teratol. 2011 Apr;91(4):218-25.

Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate.
Nikopensius T, Jagomägi T, Krjutskov K, Tammekivi V, Saag M, Prane I, Piekuse L, Akota I, Barkane B, Krumina A, Ambrozaityte L, Matuleviciene A, Kucinskiene ZA, Lace B, Kucinskas V, Metspalu A.
Birth Defects Res A Clin Mol Teratol. 2010 Sep;88(9):748-56.

Susceptibility locus for non-syndromic cleft lip with or without cleft palate on chromosome 10q25 confers risk in Estonian patients.
Nikopensius T, Birnbaum S, Ludwig KU, Jagomägi T, Saag M, Herms S, Knapp M, Hoffmann P, Nöthen MM, Metspalu A, Mangold E.
Eur J Oral Sci. 2010 Jun;118(3):317-9.

MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate.
Jagomägi T, Nikopensius T, Krjutskov K, Tammekivi V, Viltrop T, Saag M, Metspalu A.
Eur J Oral Sci. 2010 Jun;118(3):213-20.

Epidemiologic factors causing cleft lip and palate and their regularities of occurrence in Estonia.
Jagomagi T, Soots M, Saag M.
Stomatologija. 2010;12(4):105-8.

Replication of novel susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24 in Estonian and Lithuanian patients.

Nikopensius T, Ambrozaityte L, Ludwig KU, Birnbaum S, Jagomägi T, Saag M, Matuleviciene A, Linkeviciene L, Herms S, Knapp M, Hoffmann P, Nöthen MM, Kucinskas V, Metspalu A, Mangold E.
Am J Med Genet A. 2009 Nov;149A(11):2551-3.
Research grant funding received:Yes
Details of funding:ETF grant (ended 2011)
Estonian Research Council (new applications available)
We will apply for speech project.
Willing to share Powerpoint presentations:Yes

EU Biobank

Stored CLP DNA samples available for use in future studies:

Number for CP:we do need negotiate about that, we can start collecting trios, we do have few, we do have dna samples from cleft children. But we have special rules for that and we do need acceptance from Research Ethics Committee

Potential clinical research activities

Clinical research activities interested in being involved in:

Randomised clinical trials:Yes
Inter-centre comparison of outcome:Yes
Prospective study:Yes
DNA collection:Yes

Potential laboratory based research activities

Laboratory based research activities interested in being involved in:

Laboratory genetics/genomics research:Yes
Animal models research:Yes

National cleft lip and palate / craniofacial scientific organisation

Organisation details:Triin Jagomägi
+372 5153634

Useful websites or links

Useful websites or

Total number of cases per annum

Total cases per annum:14 (2011)