Cleft Centre, University Department of Maxillofacial Surgery, University Hospital Ljubljana

Principle contact details

Contact name:Vesna Koželj
Address:Vodnikova c.25, 1000 Ljubljana

Other team members

Surgeon:Andreja Eberlinc, Maxillofacial, Miha Ko?ar, Maxillofacial
Speech therapist:Ana Jarc
Orthodontist:Martina Drevenšek
Clinical geneticist:Borut Peterlin
Otolaryngologist:Irena Ho?evar Boltežar
Specialist nurse:Tatjana šabec
Psychologist:Petra Bav?ar
Patient follow up:Maxillofacial Surgeon

Annual case load

Cleft palate:8
Pierre Robin:4
Cleft lip & palate (CLP) Unilateral (UCLP):10
Bilateral (BCLP):1
Cleft lip (CL) Unilateral (UCL):6
Bilateral (BCL):1
Number of syndromic cases:Yes

Primary surgical protocol

Timing of first repair and type of operation.

Complete UCLP:6 months, Tenisson
Complete BCLP:6 months Manchester
Isolated CP:2 years Modified Veau

Record collection protocol

Are records routinely collected at specific ages?Yes
Does this conform to WHO timing recommendations
(birth, 5, 10, 15 and 20 years)?

State coverage of costs

Are the costs of the following treatments covered by the state (free to the patient)?

Surgery costs:All
Orthodontic costs:All
Speech and language therapy costs:All
Comments on the service provision:Centralised treatment, prenatal counseling provided by the surgeon,
regular follow up by the team - surgeon, phoniatrician, orthodontist,

Clinical research

Clinical team members who are or would like to be involved in clinical research:

Member details:inter-centre comparisson:
Andreja Eberlinc, Miha Ko?ar, Vesna Koželj, Irena Ho?evar-Boltežar, Martina Drevenšek

Non-clinical and laboratory research

Non-clinical and laboratory team members who are or would like to be involved in clinical research:

Member details:Ksenija Geršak, Vita Dolžan; gene polymorphism

Current research activity and data collection

Type(s) of software used:DNA collection - isolated CP (mother &child)
Participation in inter-centre studies:Yes
Details of studies:growth results at the adulthood: UCLP, BCLP
Participation in other collaborations (projects):Yes
Published research papers:Yes
Details of publications:Ho?evar-Boltežar I, Jarc A, Koželj V. Ear, nose and voice problems in children with orofacial clefts. J Laryngol Otol 2006; 120(4):276-81.
Zemann W, Mossbock R, Karcher H, Koželj V. Sagittal growth of the facial skeleton of 6-year-old children with a complete unilateral cleft of lip, alveolus and palate treated with two different protocols. J Craniomaxillofac Surg 2007; 35(8):343-9.
Koželj V. Experience with presurgical nasal molding in infants with cleft lip and nose deformity. Plast Reconstr Surg 2007; 120(3):738-45.
Zemann W, Karcher H, Drevenšek M, Koželj V Sagittal maxillary growth in children with unilateral cleft of the lip, alveolus and palate at the age of 10 years : an intercentre comparison. J Craniomaxillofac Surg 2011; 39(7):469-74.
Eberlinc A, Koželj V. Incidence of residual oronasal fistulas : a 20-year experience. Cleft Palate Craniofac J, 2011, doi: 10.1597/10-146.
Koželj V et al. Palate dimensions in six-year-old children with unilateral cleft lip and palate; a six-center study on dental casts. Cleft Palate Craniofac J, 2011, doi: 10.1597/10-190.
Research grant funding received:Yes
Willing to share Powerpoint presentations:Yes

EU Biobank

Stored CLP DNA samples available for use in future studies:

Number for CP:About 100 CP duo (mother, child)

Potential clinical research activities

Clinical research activities interested in being involved in:

Inter-centre comparison of outcome:Yes
Prospective study:Yes
DNA collection:Yes

Potential laboratory based research activities

Laboratory based research activities interested in being involved in:

Laboratory genetics/genomics research:Yes

National cleft lip and palate / craniofacial scientific organisation

Organisation details:NO

Total number of cases per annum

Total cases per annum:30 (25-35)